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Premarin tablets are used to treat symptoms of menopause
such as hot flashes, vaginal dryness, etc.


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Premarin tablets are used to treat symptoms of menopause such as hot flashes, vaginal dryness, etc. They have estrogens. Estrogens are important in the development and maintenance of the female urogenital system and secondary sex characteristics.

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Conjugated estrogen is a mixture of estrogen hormones, mixed to represent the average composition of material obtained from pregnant mare’s urine. It contains the sodium salts of water-soluble sulfate esters of estrone, equilin, and 17 a-dihydroequilin. The pharmacologic effect of premarin is similar to those of endogenous estrogens.

Indications

Premarin is very effective in eradicating menopause symptoms. It can also be used to treat cancer. Osteoporosis i.e., bone loss is also prevented through this medication. Estrogen holds primary importance for the both bone development and regulation of menstrual cycle. Hence, this drug is proved to be effective in treating both of these problems.

Conjugated estrogens are also efficient in treating prostrate cancer and breast cancer.

It is primarily indicated in conditions like Oestrogen deficiency, osteoporosis, urethritis, vaginitis. It can also be prescribed in adjunctive therapy as an alternative drug of choice in Abnormal uterine bleeding.

Women who do not suffer from menopause symptoms, this drug is then only prescribed if the woman is in greater danger of developing osteoporosis and cannot be treated with other medicines normally administered to treat osteoporosis. This medicine is also prescribed in a situation where the tissues of the vagina become weak (vaginal atrophy or atrophic vaginitis). But if you don’t suffer from any of the symptoms listed above then a premarin cream that is applied to a skin is a much better option for you. This medicine is also prescribed for the development of estrogen hormones in conditions where the body is no longer able to produce estrogen on its own. It is also proved to be very effective in treating men with developing prostate cancer when all other treatments are unsuccessful.

Side effects

Common side effects are breast tenderness, increased hair growth, freckles, vaginal itching, decreased sex drive, dizziness, and headache.

You need to consult your doctor immediately if you experience difficulty in breathing or discover swelling in your face and lips.

Though a very serious reaction can rarely happen but don’t be late in calling your doctor urgently if you experience any of these symptoms.

The comprehensive study proposes an elevated risk of breast cancer in women taking combined estrogen-progesterone and also who have undergone Hormonal Replacement Therapy.

The Women's Health Initiative trial (WHI) suggested less chances of development of breast cancer in women who got their uterus or part of their uterus surgically removed. This research has described the slightest chance in the danger of having breast cancer diagnosed that is substantially lower than that observed in users of estrogen-progestogen combinations

For all Hormonal Replacement Therapy, an elevated danger becomes evident within a few years of use and increases as time passes, but it disappears within a few years after quitting the treatment.

Hormonal Replacement Therapy, particularly estrogen-progesterone combined treatment, increases the denseness of mammographic images. It has an unfavourable effect on the radiological investigation of breast cancer.

Secondly, ovarian cancer rarely happens. Epidemiological proofs from a great scale analysis propose a small elevated risk in women taking estrogen-only or combined estrogen-progesterone Hormonal Replacement Therapy. It becomes evident within few years of use, and it disappears when we quit taking medicine. Other studies propose that combined estrogen-progesterone usage may cause a small risk of development of ovarian cancer.

Hormone replacement therapy (HRT) could be a cause of development of venous thromboembolism. It means deep vein thrombosis or pulmonary embolism. It can happen within the first year of Hormonal Replacement Therapy.

Patients who have a medical history of venous thromboembolism i.e., it runs in their family, Hormonal Replacement Therapy can elevate their risk of developing it too.

Women who are suffering from Coronary Artery Disease have no risk of myocardial infarction. Studies suggest that women who received combined estrogen-progesterone or only estrogen Hormonal Replacement Therapy don’t develop coronary artery disease. Additionally, there is no danger of developing coronary artery disease in women who got their uterus surgically removed.

Combined estrogen-progestogen and estrogen-only therapy are linked with elevation in the danger of ischaemic stroke. Women who use Hormonal Replacement Therapy will suffer from an increased risk of ischaemic stroke.

Prolonged administration of estrogen in women who have an unharmed uterus will increase the danger of developing endometrial hyperplasia and carcinoma In women with an intact uterus the risk of endometrial hyperplasia and carcinoma. The elevation in the danger of endometrial hyperplasia is observed more among women who use estrogen-only hormonal replacement therapy. Even if they stop using the treatment, the danger of developing endometrial hyperplasia still remains elevated.

Use of progesterone or combined estrogen-progesterone therapy may eradicate the risk of developing diseases with estrogen-only therapy.

Fluid retention is very commonly observed in only estrogen therapy. Hence, patients who suffer from renal dysfunction should be strictly monitored.

Use of estrogen can also affect the research facilities result of endocrine tests.

Estrogens may also elevate thyroid binding globulin (TBG), resulting in increased thyroid hormone production.

Other binding proteins can also be raised in serum due to prolonged estrogen use. These include corticoid binding globulin (CBG), sex-hormone-binding globulin (SHBG) resulting in elevated circulating corticosteroids and sex steroids. Free hormones have no effect of increased estrogen levels. The increase in other plasma proteins is also observed such as angiotensinogen/renin substrate, alpha-I-antitrypsin, ceruloplasmin.

Patients who have undergone thyroid replacement therapy may need excessive doses so that thyroid levels could be regulated. Hence, patients need to get their thyroid levels strictly checked by the doctor.

Diabetic patients need to be extra careful while undergoing hormone replacement therapy. Excessive estrogen can affect glucose tolerance as well.

Contraindications

It is contraindicated in conditions like Breast Cancer, Genital tract bleeding, Thromboembolism, Thrombophlebitis, Endometrial hyperplasia, Porphyria and Acute Liver disease.


     

Menopause

Menopause means the end of your menstrual cycle. Women can’t bear children any longer afterward. It causes a complete stop on fertility, but one can still enjoy her sexual life to the fullest. Some women get happy because they no longer need to worry about pregnancy. Before menopause, a woman's periods typically become eccentric. This situation indicates that periods may be longer or shorter in duration or be lighter or heavier in the quantity of flow. Though the average age of menopause is 51 but it varies.

   

Menopause-Premarin

   

Symptoms of menopause

  • Irregular periods
  • Vaginal dryness
  • Hot flashes
  • Sleep problems
  • Mood changes
  • Loss of breast fullness

Irregular periods

Irregular periods are often the first symptom that woman experiences. They can happen due to hormonal disturbances. A woman usually starts having irregular periods 7 to 8 years before menopause. There is also a possibility that some women might not experience it at all and their menstrual cycle remains normal till the menopause.

Two hormones, estrogen, and progesterone are important for the regulation of normal periods. Estrogen prepares the uterine lining for ovulation and progesterone causes shedding of uterine contents if fertilization doesn't happen. When a woman reaches 45, her progesterone and estrogen level starts falling. The fluctuation in the level of these two hormones is the prime cause of irregular periods.

Vaginal dryness

Vaginal dryness is a very prevalent symptom that a woman could experience before menopause. Basically, the vaginal lubrication is caused by the glands at the neck of the cervix. They keep it moist and lubricated. Vaginal lubrication gets increased during sexual excitement to aid the intercourse. Apart from bolstering the sexual activity, moisture keeps the vagina clean. Some of the women start complaining about vaginal dryness before the menopause. The reason could be the lack of sexual foreplay, or they are not fully aroused. Such types of women feel pain during the sex. Decreasing hormonal levels can also lead to vaginal dryness. Since estrogen causes thickening of the uterine lining, its fluctuating level might cause vaginal lining to become less elastic and thin, and it could get damaged easily. Some drugs like antidepressants and health care products like soaps etc. can also result in vaginal dryness. It affects a woman's everyday life. They are not even able to perform the normal activities like they have a difficulty in standing, sitting, urinating, etc.

Hot flashes

A hot flash is the most common and the frequent symptom of menopause. It is an inside feeling of heat and warmth. Redness of skin and sweating also happens. Symptoms last from seconds to a few minutes. A woman can experience it for years after the menopause. A problem in temperature regulation of body could result in hot flashes. Additionally, the falling levels of estrogen and the aging process can be other causes. Sometimes, extreme perspiration and palpitation is observed. Hot flashes along with sweating at night are called night sweats. They can also occur due to some medication which disturbs the thermal regulation of our body.

   

Women-Menopause

   

Sleep problems

Menopause is the condition when ovaries stop producing adequate amounts of hormones. This results in hot flashes, sweating, vaginal dryness, irritation, breathing problems. All these factors, affect the normal sleeping cycle of a woman and they have difficulty sleeping at night. They also remain drowsy all day.

Mood changes

Mood changes are a very noticeable symptom before menopause. Other symptoms like vaginal dryness and hot flashes could also be the reason for her irritation and frustration. Menopause can also prompt aggressiveness, tension, fatigue, anxiety, etc. Women face difficulty in remembering things. They become sad and depressed. They experience a lack of motivation and inability to do anything properly.

Loss of breast fullness

Aging process brings about many changes in the body. As time passes, breast tissues start to change. They lose their firmness and thickness. That's because of decreasing hormonal levels. Deficiency of estrogen not also causes vaginal lining to become thin, but it also results in less elasticity of connective tissue of our breasts leading to the hanging of breasts.

Warnings

You should always consult your doctor before taking any drug. Similar is the case with Premarin. A patient with a medical history needs to take extra precautionary measure before using this medication. Premarin-tablets The problems may include high blood pressure, diabetes, migraine headaches, seizures, breast lumps and cancers, liver disease, heart disease, kidney disease, depression, toxemia (high blood pressure during pregnancy) , jaundice during pregnancy, uterine fibroid tumors, excessive fluid retention and weight gain during pregnancy.

This drug is very dangerous to be used during pregnancy and lactation. It may cause fetal harm. Cigarette smoking can increase the chance of blood clots while using this medication.

Higher strengths are more likely to cause melasma (darkening of the skin). Sunlight can intensify this darkness. So, avoid prolonged sun exposures.

If any of the conditions like Cholelithiasis, Epilepsy, Asthma, Otosclerosis, Adenoma and Breast Cancer are present, then the patient should be strictly supervised.

The therapy should be discontinued immediately if you experience increase in blood pressure, jaundice or become pregnant.

Dosage

Patients are usually prescribed with lowest effective dose, and it can vary person to person. It depends upon how does the patient’s body respond to the medicine. Usually, 0.3 mg is the best dosage for women.

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The tablet should be taken as a whole. Take this tablet orally with or without food. If menopause symptoms are not efficiently controlled, only then higher doses may be prescribed.

You need to take this medication regularly for the required results. Do not increase your dosage and take it longer than prescribed.

     

     

     

Comment

     

     

     

Lady Mall 23:56:29 08/07/17

Premarin is a wonderful remedy. I accepted it and not only me. I brought it from Italy, Turkey, etc., we did not have it. In 63 years on ultrasound the doctor told me that I have ovaries of 40 women, although I run and give birth. He does not give "hairiness," weight gain, and has many indications for women at this age.


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